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Post vaccination illness

A 28yr/F by name___resident of ___Home maker by occupation from a low socioeconomic class , presented with complaints of  fever( low grade ,intermittent ) associated with generalized weakness  for the duration of 2 days , Shortness of Breath (Acute  , Sudden in Onset, Grade 4 type  according to MRC scale of Dyspnea, aggravated on walking) since morning.

Negative History to rule out other systems

No History of Cough with expectoration ,Loss of weight, Travel to endemic places, Food allergy, TB contact, animal exposure

No history of Orthopnea, Paroxysmal Nocturnal Dyspnea, Chest pain, palpitations, syncope

No history of Pedal Edema, Polyuria/oliguria, burning micturition, Diarrhoea, vomiting

Past History

No history of Bronchial Asthma/DM/HTN/Seizures/TB

Drug History

History of COVISHIELD Vaccination 2nd dose 3days back, No other relevant medical history

Family History

No similar complaints in the family/ No TB suspected cases/Pneumonia/allergies

Personal History

Doesn't smoke and doesn't take alcohol
Mixed diet , loss of appetite, 
Sleep duration- regular, 
Bowel and bladder habits- normal 

Occupational History- Not relevant (Home maker)

*Consent Should be taken and explain what you are doing

 General Examination
 
Patient is conscious, coherent, well built and nourished
 
{EYE Signs- Horners Syndrome, Phylcten, Iridocyclitis, Chemosis.

External markers for TB- Taenia versicolor, epididymo orchitis, scrufuloderma, Lupus vulgaris, erythema nodosum 

External markers for Cor Pulmonale- JVP, pedal edema, Ascites, Liver enlargement

Muscle wasting, Staining of Tobacco, Asterixis to be ruled out.

Vitals
 
BloodPressure- 104/68mm Hg , supine position (Rt -arm)
 
SP02- 99% at Room Air ,Post Exercise- 98% at Room Air

Temp-febrile (99.8°F)
 
Pulse Rate- 138/min, Regular rhythm, Normal Volume and character, No vessel wall thickening,No Radio radial Delay

No Signs of Pallor, Icterus, Cyanosis, Clubbing, Pedal Edema and Generalized Lymphadenopathy.

Systemic Examination

Respiratory System Examination

Inspection- Normal

Shape of the Chest Normal AP to Transverse Diameter-5:7 (Hutchinson Index)

Flat chest- PTB/ Fibrothorax

Barrel Chest - AP:T- 1:1(Infants/old age/Emphysema/COPD)

Pectus Carinatum(Pigeon Chest)- forward protrusion of sternum- Childhood Astma,Rickets,Marfans Syndrome
 
Pectus excavatum(Cobblers/Funnel) -exaggeration of Normal hollowness over lower end of sternum- Marfans Syndrome

Harrison sulcus- indrawing of ribs to form grooves along the coastal margin to form sulcus around the diaphragm- rickets, asthma

Scorbutic rosary- backward displacement of sternum- Vit C deficiency

Rickety rosary-bead like costochondral junction

Symmetry of the Chest- dropping of the shoulder, wasting, supra clavicular and infra clavicular hollowing, crowding or bulging of the ribs 

Trachea - midline/any deviation 
Apex beat- Visible
Accessory muscles- Intercostal muscles indrawing, Sternocleidomastoid , subcostal retraction

Spine- Central /Kyphosis(Forward bending)/Scoliosis (lateral bending)/ kyphoscoliosis

Any Visible scars, pulsations, dilated veins, sinuses


Movement in all areas- equal/not
Areas
Supra clavicular
Infra clavicular
Mammary
Inframammary
Axillary
Infra axillary
Supra scapular
Inter Scapular
Infra Scapular


Palpation- 22/min, thoraco abdominal type

Rate- 14-18/min adults
Type- thoraco abdominal (females)
Abdomino thoracic (male)

Pulse to Resp rate- 4:1

Tachypnoea- >20/min 
Fever/Hypoxia/Nervousness/Pul.Edema/Pul.embolism/Pneumonia/ARDS

Bradypnoea- Alkalosis/Narcotics drug poisoning/Raised Intra cranial pressure/Hypothyroidism

Hyperpnoea- Acidosis/Hysteria/Brain Stem Lesion


Rhythm

Inspiration - contraction of external Intercostal and diaphragm- active process

Expiration- passive- elastic recoil of lungs

Accessory muscles-Inspiration- Scalene, Trapezius, Pectoral

Accessory muscles-Expiration- Lattissimus and Abd Muscles


Abnormal breathing pattern

Regular abnormal

Cheyne Stokes- Hyperpnoea followed by apnoea
Renal/Cardiac Failure, Narcotics drug poisoning, Raised ICT.

Kussmaul's - increase in rate and depth of breathing
Acidosis, Pontine Lesions

Irregular Abnormal

Biots breathing- apnoea between shallow or deep inspiration- meningitis

Ataxic breathing- Brain Stem Lesions- irregular shallow and deep breaths.

Apneustic breathing pattern - pause at full inspiration and followed by pause at full expiration for 2-3sec - Pontine Lesions


Any location rise of temperature- yes

Trails sign - undue prominence of clavicular head of SCM to the side of deviated trachea 

Any Tracheal Deviation- No
Towards the lesion- collapse of lung/Pnuemonectomy/fibrosis
Away from the lesion of lung- massive Pleural Effusion/tension pneumothorax
Upper mediastinal mass- lung cancer/lymphoma/Retrosternal goitre

Apex beat- shifted towards the side of mediastinal shift

Palpable Rub/Rhonchi/Crepitus- No

Bony rib/chest wall tenderness- empyema/amoebic liver abscess/inflammation of parietal pleura/osteomyelitis


Vocal fremitus- ulnar border of hand in all areas by vocal cord in action.
Increased in consolidation
Decreased in Pleural Effusion

Measurements
Chest Circumference
AP and Transverse Diameter
Chest expansion in inspiration and expiration
Hemithorax and hemithorax expansion- B/L

Normal expansion- 5-8cms
Severe Emphysema<1cm

Restricted expansion of chest
Systemic sclerosis (hide bound chest)
Ankylosing spondylitis
ILD
COPD

Asymmetric expansion of chest
Pneumothorax
Pleural effusion
Pulmonary fibrosis
Pulmonary collapse

Movement in all areas- normal


Percussion- Resonant note heard

Anterior Chest Wall

Direct percussion- within medial 1/3rd of clavicle

Supraclavicular fossa region (Kronigs isthmus)- direct percussion on supraclavicular fossa band of 5-7 cm size of resonance to assess the lung apices

2nd to 6th ICS  

Liver Dullness
5th rib down Mid clavicular line  (Right side)


Lateral Chest Wall
4th - 7th ICS

Liver Dullness
8th rib( right) downward mid axillary line


Posterior Chest Wall
Suprascapular- above spine of scapula
Interscapular
Infrascapular- till 11th rib

Liver Dullness percussion from 10th rib down along the mid scapular line



Percussion note
Resonant- Normal
Hyperresonant- Pneumothorax
Dull- Pulmonary collapse/severe-pulm.fibrosis/consolidation
Stony dull- pleural effusion/Haemothorax

Liver span
8-12cms in mid clavicular line

Tidal percussion

To differentiate dullness caused by liver enlargement in the 5th rib on deep inspiration, previous dull note become resonant- indicates dull note is because of liver pathology which is pulled down by right hemidiaphragm in absence of diaphragm paralysis

If still dull note - rt sided parenchymal/pleural pathology

Shifting dullness-
Shift of Dullness in hydropneumothorax- dull note in axilla on sitting becomes resonant on lying down on healthy side 

Traube space - 6th rib superior, lateral-left  mid axillary line and left Coastal margin inferiorly

*Dull note in 
Massive pericardial effusion
Left side Pleural Effusion
Fundus mass
Enlarged left lobe of liver
Splenomegaly

Shifted upwards in

Left Lung collapse/fibrosis/diaphragm paralysis


Auscultation- Bilaterally Normal vesicular breath sounds heard over all areas of auscultation.

Vocal Resonance- equal in all areas.

Amplitude and quality of VR.

Bronchophony- unclear words with  voice sounds heard over ear piece of stethoscope.- consolidation

Aegophony- E to A sign nasal or bleating quality
Consolidation, cavity

Whispering pectoriloqy- whisper words  at the end of expiration which are heard clearly- pneumonic consolidation.



Auscultation alternative on both sides
Anterior from above clavicle to 6th rib
Lateral axilla to 8th rib 
Posterior down till 11th rib



Vesicular breath sounds
Low pitched, rustling in nature, produced by attenuating and filtering effect of lung.
No pause between end of inspiration and beginning of expiration, with inspiration phase is longer than expiration in 3:1

Decreased in Pneumothorax, Collapse, COPD, obesity, thick chest wall



Bronchial breath sounds
Loud and High pitched, with passage of air through bronchi and trachea, gutteral quality , pause between inspiration and  expiration with inspiration phase is short , 


Best heard over trachea and large airways  between Scapular and above clavicle, lung apices

Causes- Pneumonia, Consolidation, Collapse, pulm fibrosis, complete alveolar atelectasis

Types 
Amorphic- metallic quality- in tension pnuemothorax

Cavernous - high pitched and hollow- Cavitations

Tubular- low pitched in consolidation





Added sounds



Brochovesicular Breath Sounds 
Moderate loud and medium pitch with rustling, heard over hilar region.
Increased inspiratory phase and short expiratory phase (I=E)
Louder in increased ventilation and consolidation 







Coarse rales/crackles/crepitations
When the mucus/fluid in the alveoli collects ,it gets sticks to the alveoli causing crackling sound on inspiration (mostly early inspiration) loud low pitched.

Heard in resolving Pneumonia, Congestive Heart Failure, Bronchiectasis, COPD.




Fine rales/crackles/ crepitations
Less loud, high pitched, heard in late inspiration

Heard in acute stages of early Pneumonia, Pulmonary fibrosis, asbestosis, Occasionally CHF 




Rhonchi 
Low pitched, continuous breath sounds caused by thick fluid or mucous secretion flow through large air passages like Bronchioles and bronchi

Heard in severe bronchitis and COPD



Wheeze
Sibilant Rhonchi
Forcing air through closed airways , expiratory.

Bronchial asthma(diffuse), foreign bodies, swelling of airway and tumors ( localised wheeze-- occlusion to Bronchial tree)




Stridor
High pitched, whistling sound heard in inspiration and expiration, seen in epiglottis, croup, tumor, retropharyngeal abscess, peritonsilar abscess.




Pleural rub - creaking noise when inflamed Pleural surface rub against each other in inspiration and expiration 
Seen in TB, Pulmonary infection, infarction, pleurisy of Pneumonia



Coin test - pneumothorax

Succussion splash- Hydropneumothorax


Other systems examination


CVS- S1 S2 + heard , no murmurs 

Per Abd examination-  soft abdomen, palpable Liver, no Ascites, no hepatomegaly and splenomegaly (no organomegaly) Bowel sounds heard .

CNS- Reflexes- Normal
No Focal Neurological Deficits 

Probable Diagnosis:-Post Vaccination  illness

Side -Right/left/bilateral
Lobe- Upper/Middle/lower
Pathology- infection/inflammation/Bronchiectasis
 Etiology- post TB/Smoking/History
 
Not in Cor Pulmonale, not in respiratory failure.


Investigations:-
Haemogram
COVID test- RTPCR/Rapid Antigen Test
Chest X ray (PA view)


Differential Diagnosis

Post Vaccination  illness ( most probably) -because similar complaints seen in Vaccinated people

Acute Hysterical illness association with Vaccination-(fever+ hysterical panic attack )

Pulmonary Embolism- but Saturation is normal
Covid 19 Pneumonia- to be ruled out by RTPCR but post exercise and post walk saturation is normal.


Treatment (Rx)-
Inj Hydrocortisone 50mg IV (SOS)(SOB relieved)
Tab Paracetamol 500mg BD P.O *2days
Tab B complex &Vit C OD  P.O *3days 
Plenty of oral fluids & Healthy diet 


Evaluation and review after 2 days.

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